《Biochemistry》 Part 1 Main objectives and main contents Main objectives: Biochemistry is an important and fundamental preclinical course for advanced medical education. Biochemistry lays the foundation for other basic and clinical medical sciences. The general goal of this course is to enable students to apply the knowledge of biochemistry to understand human health and disease especially the molecular mechanisms and treatment of disease. This teaching outline is mainly constituted based on China National Medical Licensing Examination (CNMLE) and United States Medical Licensing Examination (USMLE). The teaching aims and requirements for each chapter are mainly set up at three different levels (Understand > Be familiar with > Be aware of). Main contents: Introduction UNIT I: Protein Structure and Function Chapter 1: Amino Acids Chapter 2: Structure of Proteins Chapter 3: Globular Proteins Chapter 4: Enzymes Chapter 5: Vitamins UNIT II: Bioenergetics and Carbohydrate Metabolism Chapter 6: Bioenergetics and Oxidative Phosphorylation Chapter 7: Introduction to Carbohydrates Chapter 8: Introduction to Metabolism and Glycolysis Chapter 9: Tricarboxylic Acid Cycle and Pyruvate Dehydrogenase Complex Chapter 10: Gluconeogenesis Chapter 11: Glycogen Metabolism Chapter 12: Metabolism of Monosaccharides and Disaccharides Chapter 13: Pentose Phosphate Pathway and Nicotinamide Adenine Dinucleotide Phosphate Chapter 14: Glycosaminoglycans, Proteoglycans, and Glycoproteins UNIT III: Lipid Metabolism Chapter 15: Dietary Lipids Metabolism Chapter 16: Fatty Acid, Ketone Body, and Triacylglycerol Metabolism Chapter 17: Phospholipid, Glycosphingolipid, and Eicosanoid Metabolism Chapter 18: Cholesterol, Lipoprotein, and Steroid Metabolism UNIT IV: Nitrogen Metabolism Chapter 19: Amino Acids: Disposal of Nitrogen Chapter 20: Amino Acid Degradation and Synthesis Chapter 21: Conversion of Amino Acids to Specialized Products Chapter 22: Nucleotide Metabolism UNIT V: Integration of Metabolism Chapter 23: Metabolic Effects of Insulin and Glucagon Chapter 24: The Feed-Fast Cycle Chapter 25: Diabetes Mellitus Chapter 26: Nutrition Part 2 Students International students majoring clinical medicine Part 3 Teaching hours Total 72 teaching hours Part 4 Teaching method Teaching form: multi-media instruction and self-learning Evaluation method: closed-book examination Part 5 References 1. Denise R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry, Sixth Edition. Baltimore: Lippincott Williams & Wilkins. 2014. 2. Michael A. Lieberman, Rick Ricer. Lippincott’s illustrated Q & A review of biochemistry, 1st ed. Baltimore: Lippincott Williams & Wilkins. 2010. 3. Michael A. Lieberman, Rick Ricer. BRS Biochemistry, Molecular Biology, and Genetics. Sixth Edition. Baltimore: Lippincott Williams & Wilkins. 2014. 4. David L. Nelson, Michael M. Cox. Lehninger Principles of Biochemistry. 6th ed. New York: W. H. Freeman and Company, 2013. 5. James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick. Molecular Biology of the Gene. 7th ed. New York: Cold Spring Harbor Laboratory Press, 2013. 6. Victor W. Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. Harper's illustrated biochemistry. 30th ed. 2015. New York. McGraw-Hill Companies. 7. Robert F. Weaver. Molecular Biology, fifth edition. 2012. New York. McGraw-Hill Companies.